Stages of the fatty liver
Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease, affecting around 25% of the population worldwide.
The spectrum of NAFLD encompasses different abnormalities, ranging from a simple steatosis or nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) with various degrees of inflammation, ballooning, necrosis, fibrosis, and ultimately, cirrhosis and hepatocellular carcinoma.
Since no pharmacological treatment has been approved for NAFLD, delineating the mechanisms underlying the pathogenesis of NAFLD is crucial to managing NAFLD and its comorbidities.